The Biosphere Region's 25-member Advisory Council has representatives from federal, state, and local governments as well as community groups and local universities, all working voluntarily to improve the economic and cultural well-being of local people in ways that are compatible with the internationally renowned karst landscape, particularly with respect to preventing groundwater pollution. The Mammoth Cave National Park, the Barren River Area Development District, and Western Kentucky University have renewed a cooperative agreement to promote conservation of water resources and biodiversity, economic development for healthy people and a healthy economy, and support for research and education.
The Mammoth Cave Biosphere Region is one of 28 sites in the
US Biosphere Network.