The Parkway connects Shenandoah National Park near Waynesboro, VA (Milepost 0) with Great Smoky Mountains National Park near Cherokee, NC (Milepost 469).  There are entrances and exits at all major federal and state highways and part of a Parkway experience is getting into the towns and communities of the region.  Asheville and Boone, NC and Roanoke, VA are the largest cities along the way.  In Virginia, Interstates 64, 81, and 77 all have directions for accessing the Parkway.  The same is true for Interstates 40 and 26 in North Carolina.