The Big Bend region is vast and isolated. Highway travel between destinations usually takes several hours and available services can be limited.
Mileage from Big Bend National Park Headquarters at Panther Junction to:
| Abilene - 392 miles | Alpine -100 miles |
| Amarillo - 481 miles | Austin - 474 miles |
| Beaumont - 697 miles | Big Spring - 281 miles |
| Brownsville - 634 miles | Brownwood - 398 miles |
| Carlsbad Caverns NP, New Mexico - 305 miles | Corpus Christi - 526 miles |
| Dallas - 559 miles | Del Rio - 253 miles |
| El Paso - 329 miles | Fort Davis - 128 miles |
| Fort Stockton - 127 miles | Fort Worth - 529 miles |
| Galveston - 657 miles | Guadalupe Mountains NP - 275 miles |
| Houston - 610 miles | Lajitas - 41 miles |
| Langtry - 211 miles | Laredo - 434 miles |
| Lyndon B. Johnson National Historical Park - 410 miles |
| Lubbock - 358 miles | Marathon - 69 miles |
| Marfa - 126 miles | McAllen - 577 miles |
| Midland - 242 miles | Monahans - 178 miles |
| Odessa - 222 miles | Ojinaga, Mexico - 93 miles |
| Padre Island Natl. Seashore - 543 miles | Pecos - 191 miles |
| Presidio - 92 miles | San Angelo - 300 miles |
| San Antonio - 406 miles | Sanderson - 123 miles |
| Study Butte - 24 miles | Terlingua - 28 miles |
| Van Horn - 200 miles | Victoria - 526 miles |
| Waco - 518 miles | Wichita Falls - 513 miles |
